2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

Related Products

PDF 38.29 MB

PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140210
    Amino-PEG9-amine 474082-35-4
    Amino-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG9-amine
  • HY-140845
    1,1,1-Trifluoroethyl-PEG2-azide 1835759-68-6
    1,1,1-Trifluoroethyl-PEG2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. 1,1,1-Trifluoroethyl-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    1,1,1-Trifluoroethyl-PEG2-azide
  • HY-W096162A
    NH2-PEG2-methyl acetate hydrochloride 208647-73-8 98.0%
    NH2-PEG2-methyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG2-methyl acetate hydrochloride
  • HY-141200
    Bromoacetamido-PEG3-NH-Boc 1421933-39-2 ≥98.0%
    Bromoacetamido-PEG3-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromoacetamido-PEG3-NH-Boc
  • HY-130144
    Ald-CH2-PEG3-azide 1002342-83-7
    Ald-CH2-PEG3-azide is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Ald-CH2-PEG3-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Ald-CH2-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Ald-CH2-PEG3-azide
  • HY-133438
    BCN-PEG4-hydrazide 98.0%
    BCN-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. BCN-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
    BCN-PEG4-hydrazide
  • HY-140649
    PEG-bis-amine (MW 20000) 24991-53-5 98.0%
    PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG-bis-amine (MW 20000)
  • HY-141275
    Methyltetrazine-PEG5-alkyne 1802907-97-6 98.0%
    Methyltetrazine-PEG5-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyltetrazine-PEG5-alkyne
  • HY-130888
    (+)-Biotin-ONP 33755-53-2 ≥98.0%
    (+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    (+)-Biotin-ONP
  • HY-140754
    Bromoacetamido-PEG5-DOTA 2353410-19-0 98.02%
    Bromoacetamido-PEG5-DOTA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bromoacetamido-PEG5-DOTA
  • HY-140423
    Boc-Aminoxy-PEG4-OH 918132-14-6
    Boc-Aminoxy-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Aminoxy-PEG4-OH
  • HY-140265
    DBCO-PEG1-acid 2228857-38-1
    DBCO-PEG1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG1-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG1-acid
  • HY-140219
    Azido-PEG23-amine 2172677-19-7 99.93%
    Azido-PEG23-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG23-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG23-amine
  • HY-133498
    HyNic-PEG2-DBCO 2741281-12-7 98.10%
    HyNic-PEG2-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. HyNic-PEG2-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    HyNic-PEG2-DBCO
  • HY-140247
    N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid 2183440-70-0 99.58%
    N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-(PEG2-amine)-PEG3-acid
  • HY-140656
    Biotin-PEG-Biotin (MW 1000)
    Biotin-PEG-Biotin (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG-Biotin (MW 1000)
  • HY-140382
    Ms-PEG2-MS 34604-52-9
    Ms-PEG2-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ms-PEG2-MS
  • HY-130399
    Mal-amido-PEG6-acid 1334177-79-5
    Mal-amido-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG6-acid
  • HY-141218
    m-PEG10-alcohol 27425-92-9
    m-PEG10-alcohol (Decaethylene glycol monomethyl ether) is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG10-alcohol
  • HY-135339
    Benzyl-PEG2-CH2COOH 91842-53-4
    Benzyl-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG2-CH2COOH
PROTAC Linkers Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.